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- Title
UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan.
- Authors
Stewart, Clinton F; Panetta, John C; O'Shaughnessy, Melinda A; Throm, Stacy L; Fraga, Charles H; Owens, Thandranese; Liu, Tiebin; Billups, Catherine; Rodriguez-Galindo, Carlos; Gajjar, Amar; Furman, Wayne L; McGregor, Lisa M
- Abstract
To study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and severe toxicity as well as irinotecan disposition in pediatric patients with solid tumors receiving low-dose, protracted irinotecan (15 to 75 mg/m2 daily for 5 days for 2 consecutive weeks).
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 18, p2594
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.10.2301