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- Title
Meta-analysis of BRCA1 and BRCA2 penetrance.
- Authors
Chen, Sining; Parmigiani, Giovanni
- Abstract
Genetic counseling is now routinely offered to individuals at high risk of carrying a BRCA1 or BRCA2 mutation. Risk prediction provided by the counselor requires reliable estimates of the mutation penetrance. Such penetrance has been investigated by studies worldwide. The reported estimates vary. To facilitate clinical management and counseling of the at-risk population, we address this issue through a meta-analysis.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 11, p1329
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.09.1066