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- Title
Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1.
- Authors
Tolcher, Anthony W; Mita, Monica; Meropol, Neal J; von Mehren, Margaret; Patnaik, Amita; Padavic, Kristin; Hill, Monique; Mays, Theresa; McCoy, Therese; Fox, Norma Lynn; Halpern, Wendy; Corey, Alfred; Cohen, Roger B
- Abstract
To assess the safety, pharmacokinetics, and preliminary evidence of antitumor activity of mapatumumab (HGS-ETR1, TRM-1), a fully human agonist monoclonal antibody directed to the tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1).
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 11, p1390
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.08.8898