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- Title
Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997.
- Authors
Flinn, Ian W; Neuberg, Donna S; Grever, Michael R; Dewald, Gordon W; Bennett, John M; Paietta, Elisabeth M; Hussein, Mohamad A; Appelbaum, Frederick R; Larson, Richard A; Moore, Dennis F, Jr; Tallman, Martin S
- Abstract
The combination of fludarabine and cyclophosphamide is an effective regimen for patients with chronic lymphocytic leukemia (CLL). However, it may be accompanied by increased toxicity compared with fludarabine alone. E2997 is a phase III randomized Intergroup trial comparing fludarabine and cyclophosphamide (FC arm) versus fludarabine (F arm) alone in patients receiving their first chemotherapy regimen for CLL.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 7, p793
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.08.0762