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- Title
Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma.
- Authors
Infante, Jeffrey R; Matsubayashi, Hiroyuki; Sato, Norihiro; Tonascia, James; Klein, Alison P; Riall, Taylor A; Yeo, Charles; Iacobuzio-Donahue, Christine; Goggins, Michael
- Abstract
SPARC (secreted protein acidic and rich in cysteine) is a protein involved in cell matrix interactions, wound repair, and cell migration, and has been reported to inhibit cancer growth. SPARC undergoes epigenetic silencing in many pancreatic cancers, but stromal fibroblasts adjacent to infiltrating pancreatic adenocarcinomas frequently express SPARC. We evaluated the prognostic significance of tumor and peritumoral SPARC expression in patients with pancreatic adenocarcinoma.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 3, p319
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.07.8824