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- Title
Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors.
- Authors
Rosen, Lee S; Kurzrock, Razelle; Mulay, Marilyn; Van Vugt, Andy; Purdom, Michelle; Ng, Chaan; Silverman, Jeffrey; Koutsoukos, Antonis; Sun, Yu-Nien; Bass, Michael B; Xu, Ren Y; Polverino, Anthony; Wiezorek, Jeffrey S; Chang, David D; Benjamin, Robert; Herbst, Roy S
- Abstract
AMG 706 is an investigational, orally bioavailable inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, platelet-derived growth factor receptor, and stem-cell factor receptor. This phase I, dose-finding study evaluated the safety, pharmacokinetics, and pharmacodynamics of AMG 706 in patients with refractory advanced solid tumors.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 17, p2369
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.07.8170