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- Title
Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade.
- Authors
Loi, Sherene; Haibe-Kains, Benjamin; Desmedt, Christine; Lallemand, Françoise; Tutt, Andrew M; Gillet, Cheryl; Ellis, Paul; Harris, Adrian; Bergh, Jonas; Foekens, John A; Klijn, Jan G M; Larsimont, Denis; Buyse, Marc; Bontempi, Gianluca; Delorenzi, Mauro; Piccart, Martine J; Sotiriou, Christos
- Abstract
A number of microarray studies have reported distinct molecular profiles of breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER) -positive subtypes has been inconsistent. Therefore, refinement of their molecular definition is needed.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 10, p1239
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.07.1522