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- Title
Somatic activation of KIT in distinct subtypes of melanoma.
- Authors
Curtin, John A; Busam, Klaus; Pinkel, Daniel; Bastian, Boris C
- Abstract
Melanomas on mucosal membranes, acral skin (soles, palms, and nail bed), and skin with chronic sun-induced damage have infrequent mutations in BRAF and NRAS, genes within the mitogen-activated protein (MAP) kinase pathway commonly mutated in melanomas on intermittently sun-exposed skin. This raises the question of whether other aberrations are occurring in the MAP kinase cascade in the melanoma types with infrequent mutations of BRAF and NRAS.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Vol 24, Issue 26, p4340
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.06.2984