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- Title
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous.
- Authors
Renkonen, Elise T; Nieminen, Pekka; Abdel-Rahman, Wael M; Moisio, Anu-Liisa; Järvelä, Irma; Arte, Sirpa; Järvinen, Heikki J; Peltomäki, Päivi
- Abstract
One third of families with classical adenomatous polyposis (FAP), and a majority of those with attenuated FAP (AFAP), remain APC mutation-negative by conventional methods. Our purpose was to clarify the genetic basis of polyposis and genotype-phenotype correlations in such families.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 24, p5651
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.14.712