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- Title
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia.
- Authors
Keating, Michael J; O'Brien, Susan; Albitar, Maher; Lerner, Susan; Plunkett, William; Giles, Francis; Andreeff, Michael; Cortes, Jorge; Faderl, Stefan; Thomas, Deborah; Koller, Charles; Wierda, William; Detry, Michelle A; Lynn, Alice; Kantarjian, Hagop
- Abstract
Fludarabine and cyclophosphamide (FC), which are active in treatment of chronic lymphocytic leukemia (CLL), are synergistic with the monoclonal antibody rituximab in vitro in lymphoma cell lines. A chemoimmunotherapy program consisting of fludarabine, cyclophosphamide, and rituximab (FCR) was developed with the goal of increasing the complete remission (CR) rate in previously untreated CLL patients to >/= 50%.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 18, p4079
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.12.051