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- Title
Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
- Authors
Cloughesy, Timothy F; Kuhn, John; Robins, H Ian; Abrey, Lauren; Wen, Patrick; Fink, Karen; Lieberman, Frank S; Mehta, Minesh; Chang, Susan; Yung, Alfred; DeAngelis, Lisa; Schiff, David; Junck, Larry; Groves, Morris; Paquette, Steve; Wright, John; Lamborn, Kathleen; Sebti, Said M; Prados, Michael
- Abstract
To determine the maximum-tolerated dose (MTD), toxicities, and clinical effect of tipifarnib, a farnesyltransferase (FTase) inhibitor, in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs (EIAEDs). This study compares the pharmacokinetics and pharmacodynamics of tipifarnib at MTD in patients on and off EIAEDs.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 27, p6647
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.10.068