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- Title
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.
- Authors
Attia, Peter; Phan, Giao Q; Maker, Ajay V; Robinson, Michael R; Quezado, Martha M; Yang, James C; Sherry, Richard M; Topalian, Suzanne L; Kammula, Udai S; Royal, Richard E; Restifo, Nicholas P; Haworth, Leah R; Levy, Catherine; Mavroukakis, Sharon A; Nichol, Geoff; Yellin, Michael J; Rosenberg, Steven A
- Abstract
Previously, we reported our experience treating 14 patients with metastatic melanoma using a fully human antibody to cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) in conjunction with peptide vaccination. We have now treated 56 patients to evaluate two different dose schedules of anti-CTLA-4 and to explore the relationship between autoimmunity and tumor regression.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 25, p6043
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.06.205