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- Title
Imatinib-induced regression of AIDS-related Kaposi's sarcoma.
- Authors
Koon, Henry B; Bubley, Glenn J; Pantanowitz, Liron; Masiello, David; Smith, Brad; Crosby, Katherine; Proper, Joann; Weeden, Will; Miller, Thomas E; Chatis, Pamela; Egorin, Merrill J; Tahan, Steven R; Dezube, Bruce J
- Abstract
Activation of the platelet-derived growth factor (PDGF) and c-kit receptors has been proposed as important in mediating the growth of AIDS-related Kaposi's sarcoma (KS). We investigated the response of KS to the PDGF receptor (PDGFR)/c-kit inhibitor, imatinib mesylate, and investigated the effect of this therapy on critical signal transduction intermediates.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 5, p982
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.06.079