We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The role of UGT1A1*28 polymorphism in the pharmacodynamics and pharmacokinetics of irinotecan in patients with metastatic colorectal cancer.
- Authors
Toffoli, Giuseppe; Cecchin, Erika; Corona, Giuseppe; Russo, Antonio; Buonadonna, Angela; D'Andrea, Mario; Pasetto, Lara Maria; Pessa, Sergio; Errante, Domenico; De Pangher, Vincenzo; Giusto, Mauro; Medici, Michele; Gaion, Fernando; Sandri, Paolo; Galligioni, Enzo; Bonura, Salvatore; Boccalon, Massimo; Biason, Paola; Frustaci, Sergio
- Abstract
UGT1A1*28 polymorphism has been associated with decreased glucuronidation of SN38, the active metabolite of irinotecan. This could increase toxicity with this agent.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Vol 24, Issue 19, p3061
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.05.5400