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- Title
MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior.
- Authors
Roldo, Claudia; Missiaglia, Edoardo; Hagan, John P; Falconi, Massimo; Capelli, Paola; Bersani, Samantha; Calin, George Adrian; Volinia, Stefano; Liu, Chang-Gong; Scarpa, Aldo; Croce, Carlo M
- Abstract
We investigated the global microRNA expression patterns in normal pancreas, pancreatic endocrine tumors and acinar carcinomas to evaluate their involvement in transformation and malignant progression of these tumor types. MicroRNAs are small noncoding RNAs that regulate gene expression by targeting specific mRNAs for degradation or translation inhibition. Recent evidence indicates that microRNAs can contribute to tumor development and progression and may have diagnostic and prognostic value in several human malignancies.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Vol 24, Issue 29, p4677
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.05.5194