We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma.
- Authors
Mamelak, Adam N; Rosenfeld, Steven; Bucholz, Richard; Raubitschek, Andrew; Nabors, L Burt; Fiveash, John B; Shen, Sui; Khazaeli, M B; Colcher, David; Liu, An; Osman, Medhat; Guthrie, Bart; Schade-Bijur, Susan; Hablitz, Diana M; Alvarez, Vernon L; Gonda, Matthew A
- Abstract
TM-601 binds to malignant brain tumor cells with high affinity and does not seem to bind to normal brain tissue. Preclinical studies suggest that iodine-131 (131I) -TM-601 may be an effective targeted therapy for the treatment of glioma. We evaluated the safety, biodistribution, and dosimetry of intracavitary-administered 131I-TM-601 in patients with recurrent glioma.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Vol 24, Issue 22, p3644
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.05.4569