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- Title
Risk-reducing salpingo-oophorectomy in BRCA mutation carriers: role of serial sectioning in the detection of occult malignancy.
- Authors
Powell, C Bethan; Kenley, Eric; Chen, Lee-May; Crawford, Beth; McLennan, Jane; Zaloudek, Charles; Komaromy, Miriam; Beattie, Mary; Ziegler, John
- Abstract
Women who carry deleterious mutations of BRCA1 or BRCA2 genes have up to a 54% lifetime risk of developing ovarian cancer. After childbearing, women at high risk increasingly choose bilateral risk-reducing salpingo-oophorectomy (RRSO). Two recent studies of BRCA mutation carriers reported occult malignancy in 2.5% of women undergoing RRSO. This study aimed to increase this detection rate using a protocol.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 1, p127
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.04.109