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- Title
TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia.
- Authors
Raval, Aparna; Lucas, David M; Matkovic, Jennifer J; Bennett, Kristi L; Liyanarachchi, Sandya; Young, Donn C; Rassenti, Laura; Kipps, Thomas J; Grever, Michael R; Byrd, John C; Plass, Christoph
- Abstract
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease for which natural history can be predicted based on the presence or absence of immunoglobulin (Ig) variable heavy chain (V(H)) gene mutations. Herein we report selective epigenetic silencing of the transcription factor TWIST2 (DERMO1) in Ig V(H) mutated CLL and describe a semiquantitative assay to study promoter methylation of this gene in primary tumor cells.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 17, p3877
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.02.196