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- Title
Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials.
- Authors
Sargent, Daniel J; Wieand, Harry S; Haller, Daniel G; Gray, Richard; Benedetti, Jacqueline K; Buyse, Marc; Labianca, Roberto; Seitz, Jean Francois; O'Callaghan, Christopher J; Francini, Guido; Grothey, Axel; O'Connell, Michael; Catalano, Paul J; Blanke, Charles D; Kerr, David; Green, Erin; Wolmark, Norman; Andre, Thierry; Goldberg, Richard M; De Gramont, Aimery
- Abstract
A traditional end point for colon adjuvant clinical trials is overall survival (OS), with 5 years demonstrating adequate follow-up. A shorter-term end point providing convincing evidence to allow treatment comparisons could significantly speed the translation of advances into practice.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 34, p8664
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.01.6071