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- Title
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee.
- Authors
Ellison, David W; Onilude, Olabisi E; Lindsey, Janet C; Lusher, Meryl E; Weston, Claire L; Taylor, Roger E; Pearson, Andrew D; Clifford, Steven C; United Kingdom Children's Cancer Study Group Brain Tumour Committee
- Abstract
Identifying pathobiological correlates of clinical behavior or therapeutic response currently represents a key challenge for medulloblastoma research. Nuclear accumulation of the beta-catenin protein is associated with activation of the Wnt/Wg signaling pathway, and mutations affecting components of this pathway have been reported in approximately 15% of sporadic medulloblastomas. We tested the hypothesis that nuclear immunoreactivity for beta-catenin is a prognostic marker in medulloblastoma, and assessed the relationship between nuclear beta-catenin immunoreactivity and mutations of CTNNB1 and APC.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 31, p7951
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.01.5479