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- Title
Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations.
- Authors
Agnelli, Luca; Bicciato, Silvio; Mattioli, Michela; Fabris, Sonia; Intini, Daniela; Verdelli, Donata; Baldini, Luca; Morabito, Fortunato; Callea, Vincenzo; Lombardi, Luigia; Neri, Antonino
- Abstract
The deregulation of CCND1, CCND2 and CCND3 genes represents a common event in multiple myeloma (MM). A recently proposed classification grouped MM patients into five classes on the basis of their cyclin D expression profiles and the presence of the main translocations involving the immunoglobulin heavy chain locus (IGH) at 14q32. In this study, we provide a molecular characterization of the identified translocations/cyclins (TC) groups.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 29, p7296
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.01.3870