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- Title
Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies.
- Authors
Pingpank, James F; Libutti, Steven K; Chang, Richard; Wood, Bradford J; Neeman, Ziv; Kam, Anthony W; Figg, William D; Zhai, Souping; Beresneva, Tatiana; Seidel, Geoffrey D; Alexander, H Richard
- Abstract
We conducted a phase I study of a 30-minute hepatic artery infusion of melphalan via a percutaneously placed catheter and hepatic venous hemofiltration using a double balloon catheter positioned in the retrohepatic inferior vena cava to shunt hepatic venous effluent through an activated charcoal filter and then to the systemic circulation. The purpose of the study was to demonstrate feasibility in an initial cohort and subsequently determine the maximum tolerated dose and dose-limiting toxicity of melphalan.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 15, p3465
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2005.00.927