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- Title
Phase II study of activated charcoal to prevent irinotecan-induced diarrhea.
- Authors
Michael, Michael; Brittain, MaryAnne; Nagai, Jane; Feld, Ronald; Hedley, David; Oza, Amit; Siu, Lillian; Moore, Malcolm J
- Abstract
The dose-limiting toxicity of irinotecan (CPT-11; Camptosar) is delayed-onset diarrhea, with an incidence at the grade 3 to 4 level of 20% to 35%. SN38, its active moiety, is responsible by a direct effect on mucosal topoisomerase-I. The aim of this study was to assess whether activated charcoal (AC), possibly by adsorbing free lumenal SN38, can reduce irinotecan-induced diarrhea (CID) and optimize its dose-intensity.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Vol 22, Issue 21, p4410
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2004.11.125