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- Title
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583).
- Authors
Small, Eric J; Halabi, Susan; Dawson, Nancy A; Stadler, Walter M; Rini, Brian I; Picus, Joel; Gable, Preston; Torti, Frank M; Kaplan, Ellen; Vogelzang, Nicholas J
- Abstract
Antiandrogen withdrawal (AAWD) results in a prostate-specific antigen (PSA) response (decline in PSA level of > or =50%) in 15% to 30% of androgen-independent prostate cancer (AiPCa) patients. Thereafter, adrenal androgen ablation with agents such as ketoconazole (K) is commonly utilized. The therapeutic effect of AAWD alone was compared with simultaneous AAWD and K therapy.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Vol 22, Issue 6, p1025
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2004.06.037