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- Title
Telomerase expression predicts unfavorable outcome in osteosarcoma.
- Authors
Sanders, Robert P; Drissi, Rachid; Billups, Catherine A; Daw, Najat C; Valentine, Marcus B; Dome, Jeffrey S
- Abstract
Osteosarcoma is distinct from most cancers in that the majority of osteosarcomas lack telomerase expression and use the alternative lengthening of telomeres (ALT) mechanism to maintain telomeres. Laboratory studies suggest that compared with ALT, telomerase expression is associated with increased tumor aggressiveness. We evaluated the clinical significance of telomerase expression in human osteosarcoma.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Vol 22, Issue 18, p3790
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2004.03.043