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- Title
Serum cardiac troponins and N-terminal pro-brain natriuretic peptide: a staging system for primary systemic amyloidosis.
- Authors
Dispenzieri, Angela; Gertz, Morie A; Kyle, Robert A; Lacy, Martha Q; Burritt, Mary F; Therneau, Terry M; Greipp, Philip R; Witzig, Thomas E; Lust, John A; Rajkumar, S Vincent; Fonseca, Rafael; Zeldenrust, Steven R; McGregor, Christopher G A; Jaffe, Allan S
- Abstract
Primary systemic amyloidosis (AL) is a multisystemic disorder resulting from an underlying plasma cell dyscrasia. There is no formal staging system for AL, making comparisons between studies and treatment centers difficult. Our group previously identified elevated serum cardiac troponin T (cTnT) as the most powerful predictor of overall survival. Others have reported that N-terminal pro-brain natriuretic peptide (NT-proBNP) is a valuable prognostic marker. We sought to develop a staging system for patients with AL.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Vol 22, Issue 18, p3751
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2004.03.029