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- Title
Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group.
- Authors
Rebbeck, Timothy R; Friebel, Tara; Wagner, Theresa; Lynch, Henry T; Garber, Judy E; Daly, Mary B; Isaacs, Claudine; Olopade, Olufunmilayo I; Neuhausen, Susan L; van 't Veer, Laura; Eeles, Rosalind; Evans, D Gareth; Tomlinson, Gail; Matloff, Ellen; Narod, Steven A; Eisen, Andrea; Domchek, Susan; Armstrong, Katrina; Weber, Barbara L; PROSE Study Group
- Abstract
Bilateral prophylactic oophorectomy (BPO) is widely used for cancer risk reduction in women with BRCA1/2 mutations. Many premenopausal women choose to take hormone replacement therapy (HRT) after undergoing BPO to abrogate immediate symptoms of surgically-induced menopause. Thus, we evaluated whether the breast cancer risk reduction conferred by BPO in BRCA1/2 mutation carriers is altered by use of post-BPO HRT.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Vol 23, Issue 31, p7804
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2004.00.8151