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- Title
Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis.
- Authors
Weinberger, Paul M; Yu, Ziwei; Haffty, Bruce G; Kowalski, Diane; Harigopal, Malini; Brandsma, Janet; Sasaki, Clarence; Joe, John; Camp, Robert L; Rimm, David L; Psyrri, Amanda
- Abstract
We sought to determine the prevalence of biologically relevant human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OSCC). Retinoblastoma (Rb) downregulation by HPV E7 results in p16 upregulation. We hypothesized that p16 overexpression in OSCC defines HPV-induced tumors with favorable prognosis.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Vol 24, Issue 5, p736
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2004.00.3335