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- Title
Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa.
- Authors
Roman-Gomez, Jose; Castillejo, Juan A; Jimenez, Antonio; Cervantes, Francisco; Boque, Concepcion; Hermosin, Lourdes; Leon, Angel; Grañena, Albert; Colomer, Dolors; Heiniger, Anabel; Torres, Antonio
- Abstract
Cadherin-13 (CDH13) is a newly characterized cadherin molecule responsible for selective cell recognition and adhesion, the expression of which is decreased by methylation in a variety of human cancers, indicating that the CDH13 gene functions as a tumor suppressor gene. Although defective progenitor-stromal adhesion is a well-recognized feature of chronic myeloid leukemia (CML), the role of CDH13 abnormalities has not been evaluated in this disease.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Vol 21, Issue 8, p1472
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2003.08.166