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- Title
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.
- Authors
Heinrich, Michael C; Corless, Christopher L; Demetri, George D; Blanke, Charles D; von Mehren, Margaret; Joensuu, Heikki; McGreevey, Laura S; Chen, Chang-Jie; Van den Abbeele, Annick D; Druker, Brian J; Kiese, Beate; Eisenberg, Burton; Roberts, Peter J; Singer, Samuel; Fletcher, Christopher D M; Silberman, Sandra; Dimitrijevic, Sasa; Fletcher, Jonathan A
- Abstract
Most gastrointestinal stromal tumors (GISTs) express constitutively activated mutant isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are potential therapeutic targets for imatinib mesylate. The relationship between mutations in these kinases and clinical response to imatinib was examined in a group of patients with advanced GIST.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Vol 21, Issue 23, p4342
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2003.04.190