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- Title
Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer.
- Authors
Sloan, Jeff A; Goldberg, Richard M; Sargent, Daniel J; Vargas-Chanes, Delfino; Nair, Suresh; Cha, Steven S; Novotny, Paul J; Poon, Michael A; O'Connell, Michael J; Loprinzi, Charles L
- Abstract
The toxicity profile of fluorouracil (5-FU)-based chemotherapy given on 5 consecutive days at doses of 370 to 450 mg/m(2) has been well documented. A meta-analysis of six North Central Cancer Treatment Group (NCCTG) cancer control trials involving 786 patients indicated that women treated with this type of regimen experienced more severe stomatitis and leukopenia than men. After these findings, an additional meta-analysis of the toxicity profiles on five NCCTG colorectal cancer treatment trials was undertaken.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Vol 20, Issue 6, p1491
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2002.20.6.1491