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- Title
Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study.
- Authors
Goodwin, Pamela J; Ennis, Marguerite; Pritchard, Kathleen I; Trudeau, Maureen E; Koo, Jarley; Madarnas, Yolanda; Hartwick, Warren; Hoffman, Barry; Hood, Nicky
- Abstract
Insulin, a member of a family of growth factors that includes insulin-like growth factor (IGF)-I and IGF-II, exerts mitogenic effects on normal and malignant breast epithelial cells, acting via insulin and IGF-I receptors. Because of this and because of its recognized association with obesity, an adverse prognostic factor in breast cancer, we examined the prognostic associations of insulin in early-stage breast cancer.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Vol 20, Issue 1, p42
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2002.20.1.42