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- Title
Factorial design considerations.
- Authors
Green, Stephanie; Liu, Ping-Yu; O'Sullivan, Janet
- Abstract
Factorial designs may be proposed to test extra questions within a clinical trial. A common approach to sample size and analysis for factorial trials assumes no statistical interactions and does not adjust for multiple testing. This investigation considered the trade-off between potential gains from testing more questions with fewer patients versus how often a factorial trial might arrive at an incorrect conclusion.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Vol 20, Issue 16, p3424
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2002.03.003