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- Title
Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans.
- Authors
Rubin, Brian P; Schuetze, Scott M; Eary, Janet F; Norwood, Thomas H; Mirza, Sohail; Conrad, Ernest U; Bruckner, James D
- Abstract
Dermatofibrosarcoma protuberans is caused by activation of the platelet-derived growth factor B (PDGFB) receptor, a transmembrane tyrosine kinase. We investigated the response of dermatofibrosarcoma protuberans to the tyrosine kinase inhibitor imatinib mesylate.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Vol 20, Issue 17, p3586
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2002.01.027