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- Title
Fluorouracil plus leucovorin as effective adjuvant chemotherapy in curatively resected stage III colon cancer: results of the trial adjCCA-01.
- Authors
Porschen, R; Bermann, A; Löffler, T; Haack, G; Rettig, K; Anger, Y; Strohmeyer, G; Arbeitsgemeinschaft Gastrointestinale Onkologie
- Abstract
Adjuvant postoperative treatment with fluorouracil (5-FU) and levamisole in curatively resected stage III colon cancer significantly reduces the risk of cancer recurrence and improves survival. Biochemical modulation of 5-FU with leucovorin has resulted in increased remission rates in metastatic colorectal cancer, thus reflecting an increased tumor-cell kill. The impact of 5-FU plus leucovorin on survival and tumor recurrence was analyzed in comparison with the effects of 5-FU plus levamisole in the prospective multicentric trial adjCCA-01.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Vol 19, Issue 6, p1787
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2001.19.6.1787