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- Title
Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study.
- Authors
Percesepe, A; Borghi, F; Menigatti, M; Losi, L; Foroni, M; Di Gregorio, C; Rossi, G; Pedroni, M; Sala, E; Vaccina, F; Roncucci, L; Benatti, P; Viel, A; Genuardi, M; Marra, G; Kristo, P; Peltomäki, P; Ponz de Leon, M
- Abstract
Germline mutations in mismatch repair genes predispose to hereditary nonpolyposis colorectal cancer (HNPCC). To address effective screening programs, the true incidence of the disease must be known. Previous clinical investigations reported estimates ranging between 0.5% and 13% of all the colorectal cancer (CRC) cases, whereas biomolecular studies in Finland found an incidence of 2% to 2.7% of mutation carriers for the disease. The aim of the present report is to establish the frequency of the disease in a high-incidence area for colon cancer.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Vol 19, Issue 19, p3944
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2001.19.19.3944