We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chromosome instability as an indicator of malignant progression in laryngeal mucosa.
- Authors
Veltman, J A; Bot, F J; Huynen, F C; Ramaekers, F C; Manni, J J; Hopman, A H
- Abstract
Routine histologic examination cannot predict whether premalignant laryngeal lesions will progress toward invasive growth. The acquisition of changes in chromosome constitution has been suggested to be essential for driving tumor progression by enhancing mutagenic mechanisms. The aim of the present study was to determine whether chromosomal changes occur in the subsequent stages of early laryngeal carcinogenesis and, if so, whether these changes can be of prognostic value.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Vol 18, Issue 8, p1644
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2000.18.8.1644