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- Title
Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial.
- Authors
Quella, S K; Loprinzi, C L; Barton, D L; Knost, J A; Sloan, J A; LaVasseur, B I; Swan, D; Krupp, K R; Miller, K D; Novotny, P J
- Abstract
Hot flashes represent a significant clinical problem for some breast cancer survivors. Safe, effective treatment is needed for this prominent clinical problem. Although it has been shown that estrogen or progesterone replacement therapy can alleviate this problem, there are continued safety concerns regarding the use of hormonal therapies in these women. Based on anecdotal information, we hypothesized that soy-derived phytoestrogens, weak estrogen-like substances in the soybean that demonstrate estrogen agonist and/or antagonist effects when they bind to estrogen receptors, could alleviate hot flashes. This current trial was designed to investigate this hypothesis.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Vol 18, Issue 5, p1068
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2000.18.5.1068