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- Title
Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children.
- Authors
Furman, W L; Stewart, C F; Poquette, C A; Pratt, C B; Santana, V M; Zamboni, W C; Bowman, L C; Ma, M K; Hoffer, F A; Meyer, W H; Pappo, A S; Walter, A W; Houghton, P J
- Abstract
In a preclinical model of neuroblastoma, administration of irinotecan daily 5 days per week for 2 consecutive weeks ([qd x 5] x 2) resulted in greater antitumor activity than did a single 5-day course with the same total dose. We evaluated this protracted schedule in children.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Vol 17, Issue 6, p1815
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.1999.17.6.1815