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- Title
Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer.
- Authors
Slade, M J; Smith, B M; Sinnett, H D; Cross, N C; Coombes, R C
- Abstract
Previous reports have indicated that reverse transcriptase polymerase chain reaction (RT-PCR) for cytokeratin 19 (CK-19) may be useful in the management of patients with breast cancer. However, the specificity of this technique is low, principally because of a high rate of false-positive results. To improve the specificity of this assay, we developed a quantitative RT-PCR methodology that enables an estimate to be made of the number of CK-19 transcripts in blood and bone marrow samples.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Vol 17, Issue 3, p870
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.1999.17.3.870