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- Title
Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.
- Authors
Clayman, G L; el-Naggar, A K; Lippman, S M; Henderson, Y C; Frederick, M; Merritt, J A; Zumstein, L A; Timmons, T M; Liu, T J; Ginsberg, L; Roth, J A; Hong, W K; Bruso, P; Goepfert, H
- Abstract
Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity and have not significantly improved survival over the last 30 years. Preclinical studies showed that adenoviral vector delivery of the wild-type p53 gene reduced tumor growth in mouse xenograft models. Our purpose was to ascertain the safety and therapeutic potential of adenoviral (Ad)-p53 in advanced HNSCC.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Vol 16, Issue 6, p2221
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.1998.16.6.2221