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- Title
Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.
- Authors
Yu, A L; Uttenreuther-Fischer, M M; Huang, C S; Tsui, C C; Gillies, S D; Reisfeld, R A; Kung, F H
- Abstract
To evaluate the toxicity, immunogenicity, and pharmacokinetics of a human-mouse chimeric monoclonal antibody (mAb) ch 14.18 directed against disialoganglioside (GD2) and to obtain preliminary information on its clinical efficacy, we conducted a phase I trial in 10 patients with refractory neuroblastoma and one patient with osteosarcoma.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Vol 16, Issue 6, p2169
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.1998.16.6.2169