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- Title
Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients.
- Authors
Gamelin, E; Boisdron-Celle, M; Delva, R; Regimbeau, C; Cailleux, P E; Alleaume, C; Maillet, M L; Goudier, M J; Sire, M; Person-Joly, M C; Maigre, M; Maillart, P; Fety, R; Burtin, P; Lortholary, A; Dumesnil, Y; Picon, L; Geslin, J; Gesta, P; Danquechin-Dorval, E; Larra, F; Robert, J
- Abstract
A relationship between fluorouracil (5-FU) dose and response has been previously shown in advanced colorectal cancer. In a previous study with 5-FU stepwise dose escalation in a weekly regimen, and pharmacokinetic monitoring, we defined a therapeutic range for 5-FU plasma levels: 2,000 to 3,000 microg/L (area under the concentration-time curve at 0 to 8 hours [AUC0-8], 16 to 24 mg x h/L). The current study investigated 5-FU therapeutic intensification with individual dose adjustment in a multicentric phase II prospective trial.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Vol 16, Issue 4, p1470
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.1998.16.4.1470