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- Title
Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein.
- Authors
Yamauchi, H; O'Neill, A; Gelman, R; Carney, W; Tenney, D Y; Hösch, S; Hayes, D F
- Abstract
Overexpression of the HER-2/c-neu/c-erbB2 proto-oncogene is associated with a worse prognosis in patients with breast cancer, perhaps due to an association of the HER-2 proto-oncogene protein with resistance to hormone and/or chemotherapy. Circulating levels of the extracellular domain (ECD) of the HER-2/c-neu-related protein (NRP) are elevated in 20% to 40% of patients with metastatic breast cancer. We investigated whether pretreatment levels of NRP predict response to hormone therapy (HT).
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Vol 15, Issue 7, p2518
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.1997.15.7.2518