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Title
Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity.
Authors
Stewart, C F; Baker, S D; Heideman, R L; Jones, D; Crom, W R; Pratt, C B
Abstract
Topotecan pharmacokinetics and pharmacodynamics were studied following a 72-hour continuous infusion in 20 children with cancer (median age, 8 years; range, 3.5 to 18).
Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Vol 12, Issue 9, p1946