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Title
Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy.
Authors
Gandhi, V; Estey, E; Keating, M J; Plunkett, W
Abstract
A protocol was designed to test the hypothesis that fludarabine infusion before arabinosylcytosine (cytarabine [ara-C]) would increase the accumulation of the active metabolite ara-C triphosphate (ara-CTP) in acute myelogenous leukemia (AML) blasts during therapy.
Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Vol 11, Issue 1, p116