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- Title
Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children's oncology group studies: a report from the children's oncology group.
- Authors
Heerema, Nyla A; Carroll, Andrew J; Devidas, Meenakshi; Loh, Mignon L; Borowitz, Michael J; Gastier-Foster, Julie M; Larsen, Eric C; Mattano, Leonard A, Jr; Maloney, Kelly W; Willman, Cheryl L; Wood, Brent L; Winick, Naomi J; Carroll, William L; Hunger, Stephen P; Raetz, Elizabeth A
- Abstract
Five-year overall survival (OS) for children with B-cell precursor acute lymphoblastic leukemia (B-ALL) exceeds 90% with risk-adapted therapy. Age, initial WBC count, genetic aberrations, and minimal residual disease (MRD) are used for risk stratification. Intrachromosomal amplification of a region of chromosome 21 (iAMP21; three or more extra copies of RUNX1 on an abnormal chromosome 21) is a recently identified recurrent genomic lesion associated with inferior outcome in some studies. We investigated the impact of iAMP21 in a large cohort treated in contemporary Children's Oncology Group (COG) ALL trials.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Vol 31, Issue 27, p3397
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2013.49.1308