We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age.
- Authors
Brugières, Laurence; Remenieras, Audrey; Pierron, Gaëlle; Varlet, Pascale; Forget, Sébastien; Byrde, Véronique; Bombled, Johny; Puget, Stéphanie; Caron, Olivier; Dufour, Christelle; Delattre, Olivier; Bressac-de Paillerets, Brigitte; Grill, Jacques
- Abstract
Germline mutations of the SUFU gene have been shown to be associated with genetic predisposition to medulloblastoma, mainly in families with multiple cases of medulloblastoma and/or in patients with symptoms similar to those of Gorlin syndrome. To evaluate the contribution of these mutations to the genesis of sporadic medulloblastomas, we screened a series of unselected patients with medulloblastoma for germline SUFU mutations.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Vol 30, Issue 17, p2087
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2011.38.7258