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- Title
Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma.
- Authors
Paugh, Barbara S; Broniscer, Alberto; Qu, Chunxu; Miller, Claudia P; Zhang, Junyuan; Tatevossian, Ruth G; Olson, James M; Geyer, J Russell; Chi, Susan N; da Silva, Nasjla Saba; Onar-Thomas, Arzu; Baker, Justin N; Gajjar, Amar; Ellison, David W; Baker, Suzanne J
- Abstract
Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of DIPGs to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 30, p3999
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2011.35.5677