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- Title
Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.
- Authors
Blanco, Javier G; Sun, Can-Lan; Landier, Wendy; Chen, Lu; Esparza-Duran, Diego; Leisenring, Wendy; Mays, Allison; Friedman, Debra L; Ginsberg, Jill P; Hudson, Melissa M; Neglia, Joseph P; Oeffinger, Kevin C; Ritchey, A Kim; Villaluna, Doojduen; Relling, Mary V; Bhatia, Smita
- Abstract
Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1 and CBR3 influence synthesis of these metabolites. We examined whether single nucleotide polymorphisms in CBR1 (CBR1 1096G>A) and/or CBR3 (CBR3 V244M) modified the dose-dependent risk of anthracycline-related cardiomyopathy in childhood cancer survivors.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Vol 30, Issue 13, p1415
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2011.34.8987